A Class is a Champion type. There are six Classes in total, and every Class has an advantage over another (called a "Class Bonus") and a disadvantage to another. Every Champion has a minimum and a maximum of one Class, though they may technically be another (e.g. Scarlet Witch is a Mutant, as she is the daughter of Magneto, but she is Mystic in-game). While there are six playable classes, a seventh class, Combined, which has a Class Bonus against all other classes, does exist. However, it is exclusive to three Unplayable champions and one Temporary champion (Summoned Symbioid)
List of Classes
Cosmic 
Cosmic Champions are characters that are alien or can be found in space. Cosmic Champions have a Class Bonus against Tech Champions, but are weak to Mystic Champions.
| List of Cosmic Champions
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Playable: Adam Warlock ● Air-Walker ● Angela ● Annihilus ● Black Bolt ● Captain Marvel ● Captain Marvel (Classic) ● Carnage (Pre-Update) ● Corvus Glaive ● Cosmic Ghost Rider ● Cull Obsidian ● Drax ● Galan ● Gamora ● Gladiator ● Gorr ● Groot ● Heimdall ● Hela ● Hercules ● Hulkling ● Hyperion ● Ikaris ● King Groot ● Knull ● Maestro (Cosmic) ● Medusa ● Ms. Marvel ● Ms. Marvel (Kamala Khan) ● Nova ● Odin ● Phoenix ● Proxima Midnight ● Red Goblin ● Ronan ● Sersi ● Silver Surfer ● Spider-Man (Symbiote) ● Super-Skrull ● Superior Iron Man ● Terrax ● Thanos ● The Champion ● The Serpent ● Thor ● Venom (Pre-Update) ● Venom the Duck ● Venompool ● Vision (Aarkus) ● Vox
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Mutant 
Mutant Champions are, as the name suggests, mutants. Mutant Champions have a Class Bonus against Skill Champions, but are weak to Tech Champions.
 List of Mutant Champions
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Playable: Apocalypse ● Archangel ● Beast ● Bishop ● Cable ● Captain Britain ● Colossus ● Cyclops (Blue Team) ● Cyclops (New Xavier School) ● Dani Moonstar ● Deadpool ● Deadpool (X-Force) ● Domino ● Dust ● Emma Frost ● Gambit ● Goldpool ● Havok ● Iceman ● Jubilee ● Kitty Pryde ● Magneto ● Magneto (House of X) ● Mister Sinister ● Namor ● Nightcrawler ● Old Man Logan ● Omega Red ● Onslaught ● Platinumpool ● Professor X ● Psylocke ● Rogue ● Sabretooth ● Sauron ● Storm ● Storm (Pyramid X) ● Stryfe ● Sunspot ● Toad ● Wolverine ● Wolverine (Weapon X) ● Wolverine (X-23)
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Mystic
Mystic Champions are characters associated with mysticism or magic. Mystic Champions have a Class Bonus against Cosmic Champions, but are weak to Science Champions.
 List of Mystic Champions
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Playable: Absorbing Man ● America Chavez ● Black Widow (Claire Voyant) ● Diablo ● Doctor Doom ● Doctor Strange ● Doctor Voodoo ● Dormammu ● Dragon Man ● Ebony Maw ● Ghost Rider ● Guillotine ● Guillotine (Deathless) ● Iron Fist ● Iron Fist (Immortal) ● Juggernaut ● Kindred ● Kushala ● Loki ● Longshot ● Magik ● Mangog ● Man-Thing ● Mephisto ● Mojo ● Mordo ● Morningstar ● Purgatory ● Rintrah ● Sasquatch ● Scarlet Witch ● Scarlet Witch (Classic) ● Sorcerer Supreme ● Spider-Man (Supreme) ● Symbiote Supreme ● The Destroyer ● The Hood ● Thor (Jane Foster) ● Tigra ● Unstoppable Colossus ● Werewolf By Night ● White Tiger ● Wiccan ● Wong
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Science
Science Champions are characters that have been scientifically altered in some way. Science Champions have a Class Bonus against Mystic Champions, but are weak to Skill Champions.
 List of Science Champions
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Playable: Abomination ● Abomination (Immortal) ● Ant-Man ● Anti-Venom ● Captain America ● Captain America (Infinity War) ● Captain America (WWII) ● Cassie Lang ● Electro ● Hulk ● Hulk (Immortal) ● Hulk (Ragnarok) ● Human Torch ● Invisible Woman ● Jessica Jones ● Joe Fixit ● Luke Cage ● M.O.D.O.K. ● Mister Fantastic ● Mister Negative ● Morbius ● Photon ● Quake ● Quicksilver ● Red Guardian ● Red Hulk ● Rhino ● Sandman ● Scorpion ● Sentry ● She-Hulk ● Silk ● Spider-Gwen ● Spider-Ham ● Spider-Man (Classic) ● Spider-Man (Miles Morales) ● Spider-Man 2099 ● Spot ● The Overseer ● Thing ● Titania ● Void ● Wasp ● Yellowjacket
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Skill
Skill Champions are characters who are good at fighting without using special powers. Skill Champions have a Class Bonus against Science Champions, but are weak to Mutant Champions.
 List of Skill Champions
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Playable: Ægon ● Agent Venom ● Attuma ● Baron Zemo ● Black Cat ● Black Panther ● Black Panther (Civil War) ● Black Widow ● Black Widow (Deadly Origin) ● Blade ● Bullseye ● Chee'ilth ● Crossbones ● Daredevil (Classic) ● Daredevil (Hell's Kitchen) ● Elektra ● Elsa Bloodstone ● Falcon ● Gwenpool ● Hawkeye ● Hit-Monkey ● Jabari Panther ● Karnak ● Kate Bishop ● Killmonger ● Kingpin ● Korg ● Kraven ● Mantis ● Masacre ● Misty Knight ● Mole Man ● Moon Knight ● Moondragon ● Nick Fury ● Night Thrasher ● Punisher ● Ronin ● Shang-Chi ● Spider-Man (Stealth Suit) ● Squirrel Girl ● Taskmaster ● Thor (Ragnarok) ● Valkyrie ● Winter Soldier
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Tech
Tech Champions are characters who are either androids or rely on technology to fight. Tech Champions have a Class Bonus against Mutant Champions, but are weak to Cosmic Champions.
 List of Tech Champions
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Playable: Ant-Man (Future) ● Captain America (Sam Wilson) ● Civil Warrior ● Darkhawk
● Doctor Octopus ● Ghost ● Green Goblin ● Guardian ● Guillotine 2099 ● Howard the Duck ● Hulkbuster ● Iron Man ● Iron Man (Infamous) ● Iron Man (Infinity War) ● Iron Patriot ● Ironheart ● Kang the Conqueror ● Lady Deathstrike ● Mysterio ● Nebula ● Nimrod ● Omega Sentinel ● Peni Parker ● Psycho-Man ● Punisher 2099 ● Red Skull ● Rocket Raccoon ● Sentinel ● Shocker ● Shuri ● Silver Centurion ● Spider-Man (Stark Enhanced) ● Star-Lord ● Ultron ● Ultron (Classic) ● Vision ● Vision (Age of Ultron) ● Viv Vision ● Vulture ● War Machine ● Warlock ● Yondu
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