Mister Sinister is a Mutant Champion. Being a Mutant Champion, he has a Class Bonus against Skill Champions, but is weak to Tech Champions.


Nathaniel Essex, a scientist in the latter half of the 19th century, pledged loyalty to the mutant-demi god Apocalypse in exchange for activation of his dormant X-Factor. Donning the moniker of Mister Sinister, Essex began to engineer bloodlines in the hope of creating the perfect mutant. His attention would eventually focus on two particularly gifted children, Scott Summers and Jean Grey. In command of the Marauders, a band of mutants that follow him, Mister Sinister has been the mastermind of many schemes and plots, not the least of which was the birth of Cyclops and Madelyne Pryor’s child, Nathan Summers, also known as Cable.


Basic Abilities


Molecular Regeneration – Passive

  • Mr. Sinister’s Regeneration Rate cannot be lowered below 0%.
  • 100% chance to Regenerate 70% of damage dealt by enemy Critical Hits over 0.4 seconds. Abilities cannot affect the Ability Accuracy, Duration, or Potency of this ability, aside from effects that would modify Mister Sinister’s Regeneration Rate.
  • Regeneration Rate is increased by 1% for every hit on the opponent’s Combo Meter up to 50 hits.

While Heavy Attack Charging

  • Pauses the duration of Damaging Debuffs, Stun, Concussion, and Power Leech on the opponent.
  • Charging a Heavy Attack for 1 second grants a Precision Buff, increasing Critical Rating by 857.14 for 6.2 seconds. This Precision provides 857.14 additional Critical Rating for each Debuff on the opponent.
  • Charging the Heavy Attack for an additional 1 second grants a Cruelty Buff, increasing Critical Damage Rating by 127.66 for 4.9 seconds. This Cruelty provides 127.66 additional Critical Damage Rating for each Debuff on the opponent.

Signature Ability

Engineered Perfection

Mister Sinister is able to improve himself with the genes of defeated opponents.

  • Each time Mister Sinister defeats an opponent, he extracts their genetic code, gaining a different Passive ability for the rest of the quest depending on the defeated Champion’s Class. [Max 3 of each Passive, 10 Passives total.]
  • Mutant: Prowess, increasing Special Attack Damage by 30%.
  • Skill: Precision, increasing Critical Rating by 500.
  • Science: Regen Rate, increasing Regeneration Rate by 20%.
  • Mystic: Power Rate, increasing Power Rate by 20%.
  • Cosmic: Fury, increasing Attack Rating by 371.4.

Special Attacks

Special 1 – Genetic Disruption

Mister Sinister sends a pulse of energy, infusing his opponent with faulty genetic material.

  • 100% chance to Transfer all Damaging Debuffs to the opponent for 4 seconds. This ability activates even if this attack is Blocked or avoided.
  • 100% Chance to cause Degeneration, inflicting 990.4 Direct Damage over 4 seconds.

Special 2 – Genetic Negation

Disabling several important genes can render the opponent powerless, in this case, it also leaves the opponent in a catatonic state.

  • 100% chance to inflict Concussion, reducing the opponent’s Ability Accuracy by 100% for 6 seconds. This ability activates even if this attack is Blocked or avoided.
  • 100% chance to Stun for 2.5 seconds.

Special 3 – Genetic Extraction

Once an exciting genetic structure is discovered, Mister Sinister takes great pleasure negating its beneficial effects and extracting its essence for himself.

  • 100% chance to inflict Concussion, reducing the opponent’s Ability Accuracy by 100% for 12 seconds.
  • 100% chance of applying Power Leech to the target, stealing 20% of Max Power over 3 seconds.


Mutant.png List of Mutant Champions Mutant.png

Playable: ApocalypseArchangelBeastBishopCableColossusCyclops (Blue Team) ● Deadpool (X-ForceGoldpoolPlatinumpool) ● DominoEmma FrostGambitHavokIcemanMagneto (House of X) ● Mister SinisterNamorNightcrawlerOld Man LoganOmega RedProfessor XPsylockeRogueSabretoothStorm (Pyramid X) ● SunspotWolverine (Weapon XX-23) ● Sunspot
Not playable: AdaptoidCyverineDeadpooloidDoombotIce PhoenixNightcarnageSentineloidSymbioidUltron Drone
Upcoming: JubileeStryfe

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